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The Multi Wire Myograph 620M is the successor to our very popular 610M Multi Wire Myograph. This 4-channel Multi Wire Myograph System is a highly sophisticated yet robust research instrument. It is an easy-to-use system for in-vitro studies of small and large blood vessels, trachea or gut mounted as larger ring preparations (up to 10 mm).

»in-vitro study of small and large blood vessels«

   The actual myograph chamber has not been changed, but the Myo-interface has been improved and re-designed:

• The heating can now be controlled in each individual bath, making remperature control   more accurate.

• The interface is more intuitive and easier to operate with a graphical color touch-display.

• The menus are easier to read and navigate. The touch screen is similar in design to a PC screen or mobile phone screen.

• The redesigned interface contains a powerful CPU and large memory capacity, allowing the 620M to be easily upgraded in the future.

Each individual myograph unit, made of aluminum, has a centrally located, round, 8 ml stainless steel chamber. The tissue supports (jaws or pins) are positioned in the chamber, where one side is attached to the force transducer and the other side is attached to a micrometer. Each unit has individually controlled gas inflow vacuum outlet. Heating and connections for vacuum and gassing are on the myograph interface, permitting the preparations in all four chambers to be kept under physiological conditions and bubbled with a gas mixture of your choice. The interface houses all the system electronics, a micro-processor for calibration, and the circuitry for analog outputs. The improved interface also contains a USB port on the back.

Following mounting and equilibration, passive length-tension relationships for the vessels are determined using a normalization procedure. This ensures reproducibility from experiment to experiment.

During actual experiments, the vessels are examind under isometric conditions by maintaining the circumference of the vessel at a constant. Compounds can be added directly to the chamber, and vessel responses due to vasopressors or vasodilators are measured in force.

»pharmacologial investigations on vessel reactivity«

This myograph is highly suited for pharmacological investigations involving vascular function. Multiple 620M units can be conveniently arranged side-by-side for larger testing capacity, thus making the 610M ideal for work requiring higher throughput, as is required in drug screening, for concentration-response curves, or in experiments where individual testing of vessels in separate baths is necessary.